Propionibacterium acnes chronic pseudophakic endophthalmitis

Propionibacterium acnes [P. acnes] is a slow-growing, anaerobic, gram-positive bacillus. P. acnes is a well recognized cause of delayed-onset, chronic endophthalmitis. It should be considered in all pseudophakic patients with chronic intraocular inflammation. The diagnosis of P. acnes endophthalmitis requires a high index of suspicion. Cultures requiring an incubation period of 10 to 14 days are necessary for definitive diagnosis. Polymerase chain reaction [PCR] carries high sensitivity and specificity rates, and is more sensitive than aqueous or vitreous cultures. A long-term follow-up period is needed to evaluate the efficacy of treatment strategies of P. acnes endophthalmitis. Reasonable treatment choices include pars plana vitrectomy and intravitreal antibiotics with either partial or total capsulectomy and intraocular lens [IOL] exchange or removal. Total capsulectomy with IOL exchange or removal almost always leads to a cure

Experimental oral chronic infection induced by actinomyces israelii and propionibacterium acnes

The purpose of this study was to evaluate an experimental animal model of oral chronic infection induced by Actinomyces israelii and propionibacterium acnes in mice. Swiss/NIH mice (n=100), 21 days of age, male and female were divided into two groups of 45 animals. A. israelii (n=45) and P. acnes (n=45) were inoculated in the anterior mandibular paraperiosteal periodontal tissue associated with sodium alginate gel particles. The animals were evaluated clinically and microscopically at 1,3,7,15,21,30 and 45 days after inoculation. Actinomycotic and propioni lesions were induced in all animals. In control mice (n=10), no lesions were noted; however, differences in the clinical and histopathological evoluations of actinomycosis and propioni lesions were observed and are discussed in this study. Microorganisms entrapped in alginate gel provided a prolonged bacterial irritation, and chronic histopathologic features similar to those seen in human actinomycosis could be detected.

Infecção oral crônica experimental induzida por actinomyces israelii e propionibacterium acnes / Experimental oral chronic infection induced by actinomyces israelii and propionibacterium acnes

The purpose of this study was to evaluate an experimental animal model of oral chronic infection induced by Actinomyces israelii and propionibacterium acnes in mice. Swiss/NIH mice (n=100), 21 days of age, male and female were divided into two groups of 45 animals. A. israelii (n=45)and P. acnes (n=45) were inoculated in the anterior mandibular paraperiosteal periodontal tissue associated with sodium alginate gel particles. The animals were evaluated clinically and microscopically at 1,3,7,15,21,30 and 45 days after inoculation. Actinomycotic and propioni lesions were induced in all animals. In control mice (n=10), no lesions were noted; however, differences in the clinical and histopathological evoluations of actinomycosis and propioni lesions were observed and are discussed in this study. Microorganisms entrapped in alginate gel provided a prolonged bacterial irritation, and chronic histopathologic features similar to those seen in human actinomycosis could be detected.